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KMID : 0616120180490030262
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Korean Journal of Pharmacognosy
2018 Volume.49 No. 3 p.262 ~ p.269
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Inhibitory Effect of Sparassis crispa (Wulf.) Extract on Monosodium Iodoacetate Induced Osteoarthritis
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Kim Eun-Nam
Roh Seong-Soo
Jeong Gil-Saeng
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Abstract
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Sparassis crispa (Wulf.) is an edible/medicinal mushroom and has been reported to biological activities such as antitumor, anti-angiogenesis, antioxidant and wound healing. However, there have not been many researches on osteoarthritis of S. crispa. The aim of this study was to investigate the effects of S. crispa extract on rats with osteoarthritis induced by MIA. Osteoarthritis is a gradually developmental disease that early stage, causes joint stiffness and complains of joint pain. In addition, it gives rise to edema and hypo-function. The results of this study, S. crispa extract effectively inhibited ROS production, increased the production of antioxidant protein SOD and catalase in knee joint cartilage tissue. In addition, S. crispa extract inhibited the expression of pro-inflammatory cytokines and enzymes such as NOX4 and P47phox, which are involved in the expression of COX-2, iNOS and the production of ROS. Also, S. crispa extract inhibited the destruction of synovial tissue, cartilage tissue and proteoglycans in articular cartilage in rats.
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KEYWORD
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Sparassis crispa (Wulf.), MIA (monosodium iodoacetate), Osteoarthritis, ROS (reactive oxygen species)
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